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Digoxin is a cardiac glycoside with an extremely narrow safety margin in pets, and it should never be given to a dog or cat unless specifically prescribed and dosed by a veterinarian. In veterinary medicine, digoxin is sometimes used under close monitoring to treat certain heart conditions, but the difference between a therapeutic and a toxic dose is small. Human formulations—especially tablets, elixirs, or higher-dose capsules—can easily deliver a dangerous amount to a pet.

Exposure most often happens when a pet chews through a pill bottle, eats dropped tablets, or licks an elixir spilled on the floor. Because digoxin is sometimes prescribed to pets in microgram-per-kilogram doses, even a single human tablet can represent a massive overdose for a small dog or cat. Cats are particularly vulnerable and may develop toxicity at doses far lower than dogs.

Early signs of digoxin poisoning include vomiting, diarrhea, loss of appetite, and lethargy. As toxicity worsens, pets may develop an irregular heartbeat, weakness, collapse, seizures, or sudden death. These effects can be delayed, so do not wait for symptoms to appear if you know or suspect your pet has been exposed.

Prevention: Store all heart medications, including digoxin, in a secure cabinet out of reach of pets. Use a pill organizer with a locking lid, and pick up any dropped tablets immediately. If your pet is prescribed digoxin, follow your veterinarian's dosing schedule exactly and keep all recheck appointments for blood testing and heart monitoring. Never share human cardiac medications with your pet.